What is Jentadueto?
Jentadueto is a combination of metformin and linagliptin. Linagliptin is an oral diabetes medicine that helps control blood sugar. Metformin reduces glucose (sugar) by decreasing the production of sugar in the liver and by decreasing the absorption by the intestines. Linagliptin regulates the levels of insulin that your body produces following a meal. Jentadueto can be used in conjunction with diet and physical activity to control blood sugar levels among adults with type II diabetes mellitus. Jentadueto does not treat type I diabetes.
Warnings
Jentadueto should not be used if you suffer from severe kidney disease or diabetic ketoacidosis. (Call your doctor to get treatment.) You may have an increased risk for lactic lacticosis. This is a dangerous buildup of lactic acid in your blood. If you experience unusual pain in your muscles, difficulty breathing, stomach discomfort, dizziness, or feel cold, call your doctor.
Tell your doctor before taking Jentadueto if you have liver or kidney disease, a serious infection, or a history of pancreatitis. You may have to temporarily stop using Jentadueto if you are going to undergo surgery or any type of x-ray or CT scan that uses a dye injected directly into your veins. You may develop lactic acidosis. If you experience unusual muscle pains, difficulty breathing, irregular heartbeats, nauseadizziness, or dizziness or feel very cold, tired, or weak, seek emergency medical attention.
Similar/related drugs
Ozempic, Mounjaro, Metformin, Trulicity, Lantus, Victoza, and Tresiba
Take this medication only if you have been prescribed it.
Jentadueto should not be used if you're allergic to metformin or linagliptin. Also, if your kidneys are severely damaged or you have diabetic ketoacidosis, Call your doctor and ask for insulin.
Tell your doctor about any of the following to ensure Jentadueto will be safe for you:
- Kidney disease
- Heart disease
- Liver disease
- Pancreatitis;
- Gallstones;
- Alcoholism; or
- High triglycerides
You could develop lac acidosis. It is more likely to occur if you suffer from other medical conditions or chronic alcoholism. Consult your doctor to determine your risk.
Jentadueto may be temporarily stopped if you are scheduled for surgery or a type of x-ray or CT scan that uses a dye injected directly into your veins. Tell your caregivers that you're taking this medication in advance. If you're pregnant or plan to become pregnant, follow your doctor's advice about Jentadueto. Jentadueto can stimulate ovulation and increase the risk of unintended pregnancies in women who are not yet menopausal. Speak to your doctor about the risks. Jentadueto should not be used by anyone under the age of 18.
How to take Jentadueto?
Follow the directions on your prescription label and read all medication guides or instruction sheets. Read all the instructions on the prescription label. If your doctor has not told you otherwise, take Jentadueto along with meals. Do not chew or crush the tablet.
You might feel very hungry or dizzy. You may also be confused, anxious, or shaky. If you want to treat hyperglycemiaquickly quickly, consume or drink something that will provide sugar fast (fruit juices, hard candies, crackers, or raisins). In the event of severe hypoglycemia, your doctor may prescribe a glucagon injectable kit. Make sure that your family and friends are familiar with how to administer this injection in case of an emergency.
Watch for signs of hyperglycemia (high blood sugar), such as increased thirst and urination. Stress can affect blood sugar levels. Other factors that may influence blood sugar include illness, surgery, or alcohol consumption. Consult your doctor before changing the dose or schedule of your medication.
Jentadueto may be part of a comprehensive treatment plan that includes diet, exercise, and weight management, as well as blood sugar testing and other medical attention. You should follow your doctor's advice. Store away from heat and moisture at room temperature.
Dosing information
Adult dosage for diabetes type 2:
Linagliptin-metformin immediate-release tablets:
Initial dose for patients not currently receiving metformin. linagliptin, 2.5 mg/metformin, 500 mg twice daily
Initial dose for patients receiving metformin. linagliptin, 2.5 mg, combined with half of the current dose of metformin orally two times a day
Initial dose for patients receiving metformin and linagliptin individually: switch to a combination product that contains the same doses for each component twice daily.
Maintenance dose: individualize dosage based on safety, efficacy, and effectiveness.
Maximum dose: linagliptin 5 mg/day; metformin 2000 mg/day
Linagliptin-metformin extended-release tablets:
Initial dose for patients not currently receiving metformin: linagliptin 500 mg/metformin 1000 mg extended-release orally, once daily
Initial dose for patients receiving metformin. linagliptin, 5 mg orally, in combination with an equivalent daily dose of metformin.
Initial dose for patients receiving metformin and linagliptin individually: Switch to combination products containing similar doses of each component, orally once per day.
Maintenance dose: individualize dosage based on safety, efficacy, and effectiveness.
Maximum dose: linagliptin 5 mg/day; metformin 2000 mg/day
Comments:
Patients taking two extended-release linagliptin/metformin tablets of 2.5 mg or 1000 mg should take both tablets at the same time, once per day.
When used with insulin or insulin secretagogues, a lower dosage of insulin or insulin secretagogues can be required to reduce the risk of hypoglycemia.
Use: To improve the glycemic level in adults with type II diabetes mellitus, as an adjunct to dietary and physical activity when both linagliptin and metformin treatment are appropriate.
What happens if I miss the dose?
If you are close to your next dose, skip the missed dose. Never take two doses of the same medicine at once.
What happens if I overdose?
Call the Poison Help Line at 1-800-222-1222 or seek emergency medical care. You may be suffering from a severe low blood sugar level (extreme weakness, vomiting, tremors or sweating, confusion, difficulty speaking, rapid heartbeats, or seizures).
Avoid these mistakes.
Avoid alcohol. Alcohol lowers your blood sugar levels and can increase the risk of lactic acidosis.
Side effect of Jentadueto
If you experience any of the following symptoms: hives, difficulty breathing, swelling on your face or in your throat, or severe skin reactions (fever or sore throat with burning eyes, skin rash, blistering or peeling skin, or red or purple rash), then seek emergency medical attention.
If you experience any of the following symptoms: severe abdominal pain that spreads to your back; vomiting and nausea; loss of appetite; or rapid heartbeats,
The mild symptoms of lactic acidosis can worsen over time. This condition is fatal. If you experience unusual muscle pains, difficulty breathing, stomach pains, vomiting, rapid, slow, or irregular heartbeats, dizziness, or feel cold or very tired, seek emergency medical attention.
If you experience:
- A severe autoimmune response Itching, blisters, and breakdown of the outer skin layer
- You may experience severe joint pain or discomfort.
- Symptoms of heart failure: shortness of breath, swelling of the legs or feet, and rapid weight gain.
Jentadueto is commonly used to treat:
- Sore throat
- Sinus pain, stuffy nose, or
- Diarrhea.
There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.
Interaction with other drug
This includes prescription and over-the-counter medicines, vitamins (https://www.drugs.com/drugclass/vitamins.html), and herbal products. These include prescription and over-the-counter medicines, vitamins, and herbal products. This list does not include all possible interactions. Inform your doctor of all medications you are currently taking and those that you will stop or start using.
