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What is Idhifa?

Idhifa targets a particular gene mutation, IDH2, that can alter the bone marrow. IDH2 mutation blocks young blood cells from transforming into adult blood cells that are healthy and can cause the symptoms associated with acute myeloid leukemia. Idhifa is a treatment for the acute leukemia in adults who carry the IDH2 mutation. Idhifa is utilized to treat AML is present or isn't improving after previous treatment.


Idhifa may cause the condition known as differentiation syndrome. This condition can affect blood cells and could be fatal if it is not treated. The condition can manifest between 10 and five months after beginning using this medication. Take immediate medical assistance If you are suffering from indications of differentiation syndrome, such as the cough or fever or breathing issues, bone pain, rapid weight gain as well as swelling on your legs, arms and groin. or neck.

Prior to use this drug

It is not recommended to take Idhifa in case you are allergic to the chemical enasidenib. Before you use Idhifa inform your physician of your medical conditions and allergies. It is possible that you will need to take an unfavorable pregnancy test prior to beginning this treatment. In studies on animals Enasidenib was linked to miscarriage, the birth of a baby with a low weight as well as birth defect. Enasidenib can harm a baby who is not yet born. Use a barrier type that provides birth control (condom or diaphragm that contains or without spermicide) to stop pregnancy while you're taking Idhifa. Contraceptives that contain hormones (birth control pills injections, implants, skin patches, vaginal rings) might not be effective enough to avoid pregnancy while you are taking your medication. It is recommended to take birth control in order to avoid pregnancy when using this medication regardless of whether you're a man or woman. Idhifa is used by parents of both and could result in birth defects. Continue using birth control for a minimum of 2 months following your previous dose of Idhifa. Inform your doctor immediately when you become pregnant when both the mother and father are taking the drug enasidenib. Idhifa could alter the fertility (ability in having kids) for both women and men. But, it is crucial to take birth control measures to avoid pregnancy since enasidenib could cause harm to the baby if the pregnancy occurs. It is unclear if it is possible to introduce enasidenib into breast milk, or if it is harmful to breastfeeding babies. Do not breastfeed when taking this medicine and at least one month after the last dose.

How to take Idhifa?

Consume Idhifa exactly as directed by your physician. Follow the directions on the prescription label. Do not take this medication in smaller or larger amounts or for a longer period than the recommended time.

Consume Idhifa exactly as directed by your physician. Idhifa is typically prescribed every day. You should take this medicine along with a glass full of water simultaneously every day. Take plenty of fluids when you take this medication. You can take this medicine in combination with food or not. Don't crush, chew or break tablets. Suck the tablet completely. Idhifa is generally prescribed until the body no longer reacts to the medication. If you have a stomach ache within a few minutes of having taken Idhifa don't take a second dose. Do your next dose according to what you are scheduled to do. There is a possibility that you require regular medical tests to make sure this medication does not cause negative consequences. The treatment you receive for cancer could be delayed depending on the findings of these tests. Keep the tablets at room temperature, free of heat and moisture. Place tablets in their original containers and the container of preservative that absorbs moisture.

Details on dosage

Usual Adult Dose for Acute Myeloid Leukemia:

100 mg orally, once a day, whether or not food

Duration of Therapy:
Treat until the disease progresses or toxicity is unacceptable.
For patients who do not have disease progression or unacceptable toxicities, you should treat them for a minimum of six months to allow a clinical response.

Comments: Select patients based on the presence of isocitrate dehydrogenase-2 (IDH2) mutations in the blood or bone marrow as detected by an FDA-approved test,

Use: Treatment for chronic or refractory acute myeloid leukemia (AML) that has the IDH2 mutation.

What happens If I miss the dose?

You can take the dose you missed on the day you remember it. The next dose should be taken at the same time, and adhere to your daily schedule. Don't make use of two doses within one day.

What happens If I overdose?

Get medical attention in an emergency or contact toll-free the Poison Help line at 1-800-222-1222.

What should be avoided?

Follow the instructions of your physician regarding any limitations on foods, drinks or activities.

Side effects of Idhifa

Take immediate medical attention If you are experiencing symptoms that you are experiencing an allergic reaction Idhifa: hives; difficulty breathing and swelling of your lips, face and tongue.

Idhifa could trigger the condition known as differentiation syndrome. This condition affects blood cells, and can cause death if not treated. The symptoms can occur between 10 days to 5 months after you begin taking Idhifa.

Get medical attention immediately If you exhibit signs of differentiation syndrome.

  • Difficulty breathing;
  • Bone pain;
  • Rapid weight increase and
  • Swelling in your legs, arms and underarms, as well as your groin or neck.

Contact your doctor immediately If you experience any of these symptoms:

  • Dark urine, stools that are coloured with clay and jaundice (yellowing of the eyes or skin);
  • Severe or ongoing vomiting or diarrhea; or
  • Symptoms of tumor cell degeneration fatigue, weakness muscles, cramps nausea, omiting diarrhea, slow or fast heart rate, fewer urinations and tingling sensations in your feet and hands and around the mouth.

Common Idhifa adverse effects could include:

  • Nausea,
  • Vomiting,
  • Diarrhea;
  • Lack of appetite

This isn't a complete list of all side effects. Other effects may also be present. Consult your physician for advice regarding medical adverse effects. You can report any symptoms to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Other medications may interfere with enasidenib. This includes prescription and over-the counter medicines as well as vitamins and herbal products. Discuss with your physician all the medicines you are currently taking as well as any medications you are about to start or stop taking.




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