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Generic Name: Etanercept ([ee-TAN-er-sept]) ee-TAN-er-sept [ ee-TAN-er-sept
Drug Classes: Antirheumatics, TNF-alpha inhibitors

What is Enbrel?

Enbrel is a tumour necrosis factor (TNF)-blocking drug. It reduces TNF, the protein that is produced by your immune system. It aids the body in fighting infections. For people suffering from autoimmune diseases, the immune system generates excessive amounts of TNF and then mistakenly attacks healthy cells.

Enbrel can be used to treat rheumatoid arthritis, psoriatic

arthritis, ankylosing spondylitis, and injuries to joints that are caused by these conditions. Enbrel can also be used to treat juvenile polyarticular arthritis in children under 2 years old. Enbrel can also be employed to manage plaque psoriasis in children and adults who are at least 4 years old.

Enbrel can be used in conjunction with methotrexate, a different medicine, to treat rheumatoid arthritis as well as psoriatic arthritis.


Utilising Enbrel can increase the chances of developing certain types of cancer, such as the rare form called lymphoma. Ask your doctor about the risk you are most at risk for. This is most often seen among young adults and teenagers who take Enbrel or similar medications to treat Crohn's disease and ulcerative colitis. Contact your doctor immediately in case you experience any of the symptoms listed below that include night sweats, fever or itching, lack of appetite or weight loss, tiredness or feeling full after eating just a small amount, discomfort in your stomach, which can extend to your shoulder, nausea, headache, easily bruising or bleeding, pale skin that is lightheaded or sluggish, rapid heart rate as well as dark urine, a stool that is clay-coloured, and jaundice (yellowing of the eyes or skin).

Enbrel may weaken our immune system. Severe and even fatal infections can develop. Call your doctor immediately if you notice signs of infection like chills, fever, or a cough; sweating; body aches; skin sores and redness burning after urination; or are feeling tired or weak.

Before you Take this Drug

It is not recommended to take Enbrel when you're sensitive to etanercept or in the case of a serious illness such as sepsis (infection all over the body).

To ensure that Enbrel is not harmful to you, consult your physician. If you suffer from:

  • A weak immune system; HIV or AIDS; tuberculosis; or any other recurring disease;

  • Signs of an active illness such as fever, flu-like symptoms, or diarrhoea; pain in the urinary tract;

  • A cut that is open or has skin ulcers;

  • Diabetes;

  • Congestive heart failure;

  • A history of neurologic diseases such as multiple sclerosis, Guillain-Barre syndrome, myelitis, or optic neuritis

  • Epilepsy, or any other seizures;

  • Asthma or another breathing disorder;

  • If you've ever experienced Hepatitis B,

  • If you're allergic to latex rubber

  • If you're scheduled to get any vaccines or have recently been vaccinated against BCG (Bacille Calmette-Guerin),

Inform your physician if you have ever suffered from tuberculosis or have been exposed to tuberculosis as indicated by a positive PPD test, whether anyone in your home suffers from tuberculosis, or if you have recently been to an area in which certain diseases are prevalent (the Ohio River Valley, the Mississippi River Valley, and the Southwest).

Children should be up-to-date on all vaccines prior to starting treatments with Enbrel.

Utilising Enbrel can increase your chance of developing certain kinds of cancer, including rapidly growing lymphoma, which can cause death. This rare lymphoma is seen in male teens and young men who are taking a combination of immunosuppressant medications to treat Crohn's disease and ulcerative colitis. However, those suffering from autoimmune conditions (including rheumatoid arthritis, Crohn's disease, ankylosing spondylitis, and psoriasis) might be at greater risk of developing lymphoma. Discuss with your physician the risk for you.

Inform your doctor if you are expecting or planning to fall pregnant while taking this medication. If you are expecting and are a candidate to be included on a pregnancy registry, This will helptrack the results of the pregnancy and assess any impacts from Enbrel in the pregnancy on your baby.

Etanercept is a drug that can be passed through breastmilk and cause harm to a nursing infant. Do not breastfeed during treatment with this medication.

How to Take Enbrel?

Before starting treatment with Enbrel, your physician may run tests to make sure you aren't suffering from an infection. Enbrel is administered under the skin. A medical professional may instruct you on the proper use of the medication on your own. Take note of and adhere to any instructions for use that are included in your medication. Ask your doctor or pharmacist if you do not know the complete instructions.

Don't shake this medication. Prepare an injection only if you are ready to administer it. Don't use it when the medicine appears cloudy, changes colour, or contains particles. Call your pharmacist to request a new medication. There is a possibility of mixing Enbrel with liquid (diluent). If you decide to inject yourself, make sure you are aware of how to combine and preserve the medication.

Etanercept dosages are determined by the weight of children. The dose requirements of your child could alter if your child is overweight or loses weight. If you are undergoing surgery, inform the surgeon beforehand that you're using Enbrel. Enbrel influences the immune system. You could contract infections more frequently and even deadly or life-threatening illnesses. Your doctor will have to check on you every few months.

If you've had the virus hepatitis B, taking Enbrel could make this virus active or make it even more serious. You may need regular liver function tests when taking this medication and for a period of time after stopping.

Follow all instructions for storage included in your medication.

  • Place Enbrel in the fridge between 36 °F and 46 °F (2 °C up to 8 °C).

  • Keep Enbrel in its original packaging to guard against physical or electrical harm.

  • If required, you can keep the syringe that is prefilled with Enbrel as well as the unmixed multiple-dose vial and diluent syringe (dose tray) at room temperature, between 68 degF and 77 degF (20 degC between 25 and 30 degC), for up to 14 days.

  • When an Enbrel syringe that has been pre filled or an unmixed vial is at room temperature, do not store it in the fridge.

  • Get rid of any Enbrel that was stored at room temperature for more than 14 days.

  • Mixture (reconstituted) Enbrel multiple-dose vials are best used immediately or stored in the refrigerator between 36 °F and 46 °F (2 °C up to 8 °C) for up to 14 days.

  • Don't store Enbrel in extreme or cold temperatures. For instance, do not store Enbrel in your car's trunk or glove box.

  • Use any product only after the time limit on the label has expired.

  • Do not freeze.

  • Don't shake.

The cartridge, injector pen, and syringe are intended for use once only. Dispose of it after just one use, regardless of whether there's still some medicine in it.

Use a needle or the syringe once only and put them into the puncture-proof "sharps" container. Make sure you follow local or state laws regarding how to dispose of the container. Make sure it is out of reach of pets and children.

What Happens if I Miss a Dose?

Contact your doctor for advice. If you have missed the medication Enbrel,

What Happens If I Overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What Should be Avoided?

Be cautious around those with illnesses or suffering from illnesses. Contact your doctor for treatment to prevent infection in the event that you have been infected with chickenpox.

Do not get a "live" vaccine while using Enbrel. The vaccine might not function at all at this point and might not completely safeguard you against disease. The live vaccines are measles, rubella, mumps (MMR), and polio; the rotavirus virus, which is a variant of typhoid; and varicella (chickenpox), as well as the more dated version of the shingles vaccination and the nasal influenza (influenza) vaccine.

Side effects of Enbrel

See a doctor immediately. If you are experiencing symptoms for an allergy reaction, Enbrel: hives; difficulty breathing; and swelling of your lips, face, and tongue.

Sometimes fatal or serious infections can happen. Call your doctor immediately if you show signs of infection like fever, chills, sweating, coughing, body aches, redness or sores, the loss of weight, a burning sensation when you go to the bathroom, coughing up blood, or feeling exhausted or short of breath.

Contact your doctor at the earliest opportunity if you are suffering from:

  • Chills, fever, flu symptoms, fever;

  • Pale skin, no bleeding or bruising

  • Discomfort, redness, or swelling after etanercept was injected (for more than 5 days following the injection);

  • Indicators of lymphoma, such as symptoms like night sweats, fever, loss of weight, stomach pain, swelling, or swelling glands (in your armpits, neck, or groyne);

  • Symptoms of tuberculosis: cough, night sweats, loss of appetite and weight loss, feeling tired and fatigued;

  • A new or worsening form of psoriasis with skin redness or bumps that are scaly, with raised areas that are swollen with pus;

  • Nerve disorders: dizziness, numbness, or tingling vision, or a weak sensation in your legs or arms;

  • Indications for heart problems such as shortness of breath or swelling of the lower legs of your feet;

  • Lupus-like Syndrome: joint swelling or pain, chest pain, being short of breath, a skin rash on your arms or cheeks (worsens in the sun),

  • Liver issues Upper stomach with right-sided fatigue, nausea, and loss of appetite. eyes, or skin. eyes.

Common side effects of Enbrel include:

  • Itching, pain, swelling, or redness in the area where the medicine was injected;

  • Headaches

  • Cold symptoms, such as congestion, sneezing, and a sore throat.

This is not a comprehensive list of all the side effects. Other side effects could occur. Contact your doctor for advice regarding medical adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.

Interaction with Other Drugs

Discuss with your physician your current medications and any new medications you begin or stop using, particularly:

  • Abatacept (Orencia);

  • Anakinra (Kineret);

  • Cyclophosphamide (Cytoxan);

  • Oral diabetes insulin medication

This list isn't comprehensive. Other medications can interfere with etanercept. This includes medications that are prescribed and available over the counter, as well as vitamins and herbal products. The interactions of all potential types are included in this guideline for medication.



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