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Cevimeline (se-vim-leen)
Brand Name: Evoxac
Dosage form: oral capsule (30 mg)
Drug class: Cholinergic agonists

What is Cevimeline?

Cevimeline stimulates the glands of saliva and sweat in the body.Cevimeline can be used to treat dry lips in people with Sjogren syndrome.Cevimeline can be used in other ways not mentioned in this guide.

Side effects of Cevimeline

If you experience any of the following signs and symptoms of an allergic reaction: difficulty breathing, hives or swelling to your face, lips or throat - seek medical help immediately!

Cevimeline may cause serious side effects. Cevimeline can cause serious side effects.

  • You may experience severe pain on your side, lower back, or stomach.
  • Vomiting;
  • Heart rate can be fast, slow, or uneven.
  • Urination that is painful or difficult
  • Feelings of dizziness may cause one to suspect possible impending doom and become lightheaded, perhaps to the point that one could pass out altogether.
  • Dehydration symptoms include feeling thirsty, hot, or unable to urinate. Heavy sweating or dry, hot skin.

Cevimeline can cause a number of side effects.

  • Increased sweating
  • Excessive salivation;
  • Nausea, diarrhoea;
  • Dry mouth
  • Headache
  • Stuffy nose.

There may be other side effects. Call your physician if experiencing side effects; alternatively, the FDA can be reached at 1-800-FDA-1088 if reporting them is necessary.


Cevimeline should not be taken if you suffer from uncontrolled asthma, glaucoma, or if your eyes are affected by iritis or uveitis.

Before you take this drug

Cevimeline should not be taken if:

  • Uncontrolled or untreated asthma;
  • Narrow-angle glaucoma (also called narrow-angle glaucoma) is a condition that affects the eyeball.
  • A condition of the eye called uveitis or iritis

Tell your doctor about any of the following to ensure that cevimeline will be safe for you:

  • Asthma, chronic lung disease (COPD);
  • Heart disease or angina (chest discomfort) and a history of heart attack.
  • A heart rhythm disorder.
  • Hypertension
  • Liver or kidney disease
  • A history of renal stones, or gallstones

This medicine is not known to harm an unborn child. Inform your physician immediately if you are pregnant, planning on becoming pregnant, or considering becoming pregnant.Cevimeline does not pass into breast milk. It is also unknown if cevimeline could harm a baby who is nursing. This medicine should not be taken while breastfeeding.Cevimeline should not be used by anyone under the age of 18.

How to take cevimeline?

Do not exceed the recommended dosage or duration. Cevimeline should not be taken in higher or lower doses or for longer than prescribed.Cevimeline can cause dehydration, so drink plenty of fluids. It will keep your kidneys functioning properly and prevent dehydration.Cevimeline should be taken three times a day. Dosage instructions should be followed by your doctor.Store at room temperature away from heat and moisture to prolong shelf life.

Details on dosage

Adult dosage for Sjogren syndrome:

Take 30 mg three times daily.
There is not enough safety information or evidence to support dosages higher than 30mg three times per day.
Use: Treatment for dry mouth symptoms in patients with Sjogren syndrome.

What happens if I miss the dose?

Once you realize you missed a dose, take it immediately. If it is close to being time for another scheduled medication dosage, avoid taking additional medicine in an attempt to make up for missing ones. Doing this may result in taking too much medicine than needed as an effort to catch up for one missed dosage could end up costing more overall than necessary.

What happens if I overdose?

Dial 1-800-222-1222 immediately or seek medical assistance when experiencing poison exposure.Overdose symptoms include headaches, vision problems, and confusion. They may also include sweating, tremors or shivering, nausea, diarrhoea, shortness of breath, and irregular heartbeats.

What should be avoided?

Cevimeline can cause blurred vision and affect your ability to think or react. You should be careful when driving or doing anything else that requires alertness and the ability to see clearly.Avoid overheating or dehydration during exercise in hot weather by staying properly hydrated. Cevimeline may decrease sweating, and you could be more susceptible to heatstroke.

Interaction with other drug

Tell your doctor if you are taking any new medications or if you will stop taking any of your current ones.

  • Antifungal or antibacterial medicine
  • Antidepressants are a type of medication.
  • Antiviral medicines to treat hepatitis C and HIV/AIDS.
  • Heart or blood pressure medications

This list is incomplete. Cevimeline may interact with other drugs, such as prescription and over-the-counter medicines, vitamins, and herbal products. This medication guide does not list all possible interactions.




Prescription only

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